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OBJECTIVE:To compare therapeutic efficacy and safety of budesonide or beclometasone combined with terbutanline in the treatment of acute attack of mild and moderate asthma in children.METHODS:A total of 110 children with mild and moderate asthma were randomly divided into group A (55 cases) and group B (55 cases).Based on routine treatment,group A was given Terbutaline sulphate solution for nebulization 1 mL,nebulization inhalation,twice a day+Budesonide suspension for inhalation 2 mL,nebulization inhalation,twice a day.Group B was given Terbutaline sulphate solution for nebulization (same usage and dosage as group A)+Beclomethasone dipropionate suspension for inhalation 2 mL,nebulization inhalation,twice a day.Treatment courses of 2 groups lasted for 7 d.Clinical efficacies,symptoms and signs disappearance time,hospitalization time,asthma relief rate as well as symptoms and signs scores,peak value expiration velocity of flow (PEF),the occurrence of ADR were observed in 2 groups.RESULTS:There was no statistical significance in total response rate,symptoms and signs disappearance time,hospitalization time,asthma relief rate or the incidence of ADR between 2 groups (P＞0.05).After treatment,symptoms and signs scores of 2 groups were significantly lower than before,while the PEF were significantly higher than before,with statistical significance (P＜0.05),but there was no statistical significance between 2 groups (P＞0.05).CONCLUSIONS:Based on routine treatment,budesonide or beclometasone combined with terbutaline sulphate can be used for acute attack of mild and moderate asthma in children.They are similar to each other in therapeutic efficacy and safety.
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OBJECTIVE:To compare clinical efficacy and safety of budesonide and beclometasone assisting with terbutaline by atomization inhalation in the treatment of acute pediatric asthma attack. METHODS:150 pediatric patients with acute asthma attack were randomly divided into group A and group B,with 75 cases in each group. Both group received symptomatic support treatment as low-flow oxygen inhalation,eliminating phlegm,relieving a cough,dilating bronchus and anti-infection,and atomization inhala-tion of budesonide,1 ml each time,bid. Based on this,group A was given atomization inhalation of budesonide,2 ml each time, bid;group B was given atomization inhalation of beclometasone,2 ml,bid. Treatment course of 2 groups lasted for 7 d. Clini-cal efficacy,asthma control,PEF% and the occurrence of ADR were observed in 2 groups;the time of symptoms and signs dis-appearance and hospitalization time were recorded,and symptoms and signs of children were scored 1 day before treatment and 7 days after treatment. RESULTS:During treatment,2 cases and 3 cases were withdraw from the test in group A and group B, respectively. The total effective rates of group A and B were 91.78% and 94.44%,and the rate of asthma control 95.89% and 94.44%,without statistical significance(P>0.05). The time of breathing difficulties disappearance,cough disappearance time, wheezing disappearance time and hospitalization time of group A were separately (2.11 ± 0.54),(3.28 ± 0.93),(4.38 ± 1.05), (5.83±1.29)d;those of B group were separately(2.07±0.52),(3.30±0.96),(4.45±1.08),(5.90±1.33)d,there was no sig-nificant difference between 2 groups(P>0.05). The clinical symptoms and signs score of group A before and after treatment were separately (4.28 ± 0.94) and (0.15 ± 0.04);those of before and after treatment of group B were separately (4.23 ± 0.91) and(0.11±0.03). There was significant difference before and after treatment(P0.05). The PEF% of group A before and after treatment were separately (51.4 ± 9.8)% and (67.2 ± 11.2)%;those of before and after treatment of group B were separately(52.0±7.1)%and(68.3±8.7)%. There was significant difference before and after treatment (P0.05). No obvi-ous ADR was found in 2 groups. CONCLUSIONS:Budesonide and beclometasone assisting with terbutaline by atomization inha-lation in the treatment for acute pediatric asthma attack possess the same effects and can efficiently relieve symptoms and signs, increase the rate of asthma control and shorten the rehabilita-tion course with good safety.
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OBJECTIVE To study the effect of using Beclomethasone Dipropionate (BDP)nasal spray on seasonal perennial allergic rhinitis. METHODS To 100 clinics indeed patients was divided into random for three groups:Cetirizine Hydyrochloeide Tablets cure 30 of set,take orally Cetirizine Hydyrochloeide Tablets 10 mg,everyday once; The BDP nasal spray 30 of set,spraying fog to BDP nasal spray, everyday 2 times,every time two per nostril(or everyday 3-4 times,every time a per nostril),dosage everyday can't over eight(400?g);Cetirizine Hydyrochloeide Tablets add BDP nasal spray to unite to cure 40 of set,using the medicine method together up.Cure time is a 7-14 days,have four times at least with visit the register, distinguish after treatment the 1 hour,the 7 days,the 14 days. Advertise for to carry on the valuation to account the cent to the nose department and a symptom,body of non-nose with observer from the sufferer, according to get a goal how much carry on the curative effect evaluation and covariances to learn the processing. RESULTS Cetirizine Hydyrochloeide Tablets and BDP nasal spray to have no obviously bad reaction towards cure the seasonal allergic rhinitis is all valid. Cetirizine Hydyrochloeide Tablets add BDP nasal spray to unite to cure a curative effect to equal the BDP nasal spray a treatment set but hight in Cetirizine Hydyrochloeide Tablets cure the set,through the x~2 examination,the difference has to statistics to learn the meaning. CONCLUSION Put together the function unite that the antihistamine and glucocorticoid,is the most valid under medical treatment the seasonal allergic rhinitis of method. Ideal treatment medicine is sine can cure the acute reaction symptom, and then cure the late hair reaction symptom.
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0.999 9).The minimum quantitative concentrations were 0.027 ?g?mL-1,0.033 ?g?mL-1,0.095 ?g?mL-1,respectively.The 3 kinds of organic solvents were not found in each batch except 0.10% and 0.15% ethyl acetate was found in 2 batches of samples.CONCLUSIONS:The established method is accurate,sensitive and accurate for the determination of 3 kinds of residual organic solvents in beclometasone dipropionate simultaneously.